xenotransplantation

O que é isso?

🎯 Dicas do simulador

📚 Glossário

Xenotransplantation

Transplante entre diferentes espécies

AlphaGal

Molécula de açúcar de porco causando rejeição hiperaguda

CRISPR

Ferramenta de edição genética para modificar o genoma do porco

Knockout

Removendo um gene do genoma

Knockin

Adicionando um gene ao genoma

HyperacuteRejection

Ataque imunológico imediato (minutos)

AcuteRejection

Ataque imunológico precoce (dias-semanas)

PERV

Retrovírus endógenos suínos

Complement

Proteínas do sistema imunológico que atacam células estranhas

Immunosuppression

Medicamentos para reduzir a atividade do sistema imunológico

🏆 Figuras-chave

David Bennett Sr.

Muhammad Mohiuddin

Liderou o programa de xenotransplante da Universidade de Maryland

George Church

Pioneiro do CRISPR, cofundador da eGenesis

Luhan Yang

CEO da eGenesis, edição de genes suínos

💬 Mensagem aos estudantes

{'encouragement': "You're learning about medicine at the frontier - technology that could eliminate the organ shortage and save hundreds of thousands of lives. Xenotransplantation is happening NOW, not in the distant future.", 'reminder': 'The first pig heart transplants have already occurred. Clinical trials are underway. This is real medicine being developed in real time.', 'action': 'Edit pig genes in the simulator. See how different modifications affect rejection. Understand the immune challenges being overcome.', 'dream': 'A surgeon from Kenya might perform xenotransplants that save lives across Africa. A geneticist from Nigeria might improve pig organ compatibility. The organ shortage is a global problem needing global solutions.', 'wiaVision': 'WIA Pin Code believes life-saving medical knowledge should reach everyone. Xenotransplantation could transform medicine in regions where donor organs are especially scarce.'}