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Amino Acid Designer
Beyond Nature's 20: Design Your Protein!
π― Choose Your Depth
Beginner
Natural 20 basics!
π€ What are Non-Natural Amino Acids?
Nature uses only 20 amino acids to build ALL proteins. But scientists have created 200+ new ones with superpowers! Add fluorine for PET imaging, click chemistry groups for precise drug attachment (Nobel Prize 2022), or D-amino acids that bacteria can't digest. FDA approved 8+ ADC cancer drugs using these in 2024!
Why revolutionary? Natural amino acids limit what proteins can do. Non-natural ones add: fluorescent tags for imaging, bioorthogonal chemistry (reactions that work only in living cells), protease resistance (drugs last longer), metal binding for catalysis.
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Cancer ADC Drugs
8+ FDA-approved antibody-drug conjugates
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PET Imaging
Fluorine-18 labeled amino acids
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Click Chemistry
Nobel Prize 2022
π‘οΈ
Protease-Resistant
D-amino acids survive digestion
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Bioplastics
Biodegradable and antimicrobial
βοΈ
Metalloenzymes
Designer amino acids with metal binding
𧬠Amino Acid Types
βοΈ Properties
Ser
Serine - Polar, Uncharged
Classification
Polar Uncharged
Molecular Weight
105.09 Da
pI (Isoelectric)
5.68
Codon(s)
UCU, UCC, UCA, UCG
𧬠The Natural 20 Amino Acids
Hydrophobic
Polar
Positive
Negative
Special
π FDA-Approved ADC Drugs Using Non-Natural Linkers
2024
Trastuzumab Deruxtecan
HER2+ breast cancer, uses topoisomerase inhibitor payload
ADC
2022
Tisotumab Vedotin
Cervical cancer, monomethyl auristatin E payload
ADC
2021
Loncastuximab Tesirine
Diffuse large B-cell lymphoma
ADC
2019
Enfortumab Vedotin
Bladder cancer, Nectin-4 targeting
ADC
2017
Inotuzumab Ozogamicin
Acute lymphoblastic leukemia
ADC
2011
Brentuximab Vedotin
Hodgkin lymphoma, CD30 targeting
ADC